IGF1R and chondrosarcoma: In fact, two cell types with distinct marker expression signatures have been isolated from primary conventional chondrosarcomas: one group of multipotent MSC origins (CD49b high/CD10 low/CD221 high), and another that resembled fibroblastic lineage (CD49b low/CD10 high/CD221 low) [34], suggesting that both chondrosarcoma cell types arose from multipotent MSC origins, the presumed origin of chondrosarcomas [34].