Dong et al. (2021) applied this method to investigate the mechanism of the Astragalus membranaceous and Angelica sinensis in the treatment of diabetic nephropathy (DN), which might treat DN by acting on vascular endothelial growth factor A (VEGFA), tumor Protein P53 (TP53), interleukin-6 (IL-6), tumor necrosis factor (TNF), microtubule affinity regulating kinase 1 (MARK1), etc., and regulate apoptosis, oxidative stress, inflammation, glucose, and lipid metabolism processes [29]. Here, TP53 is linked to diabetic kidney disease.