In addition to mediating exosome secretion in multiple types of tumour cells, syntaxin‐4, SNAP‐23, and VAMP‐7 have been implicated in diverse membrane fusion events, for example, (i) Ca2+‐triggered exocytosis of conventional lysosomes in NRK rat kidney cells (Rao et al., 2004); (ii) transportation of membrane type 1‐matrix metalloproteinase (MT1‐MMP) to invadopodia involved in ECM degradation and tumour cell invasion (Williams et al., 2014); and (iii) exocytosis of typhoid toxin upon infection of Salmonella Typhi in HEK293T cells (Chang et al., 2022). This evidence concerns the gene MMP14 and neoplasm.