In patients with AD, the top 10 DEGs in T cells included S100A8, KRT14, KRT16, HSPA1, S100A9, RPS4Y1, HSP90AA1, HSPA1B, IL13, and IL2242 (Fig. 4D–F, S4C, and S4D). Here, RPS4Y1 is linked to Alzheimer disease.