RB1 and cervical carcinoma: In the early stage, pRb is overexpressed and E7 expression is less (r-value − 0.18, P-value 0.04) in contrast to advanced stages (stage III and IV) of cervical cancer where pRb expression is very less but the expression level of HPV E7 is found significantly high then pRb (adjusted p-value 0.03).