A total of, 18 miRNAs including mir-149, mir-6525, mir-669, mir-2376, mir-24-1, mir-10162, mir-12027, mir-2300a, mir-6521, mir-1248-1, mir-1248-2, mir-615, mir-133a-1, mir-2328-3p, mir-2328-5p, mir-2400, mir-29b-1, and mir-378-1, five lncRNAs including ENSBTAG00000048401, ENSBTAG00000049095, ENSBTAG00000050346, ENSBTAG00000051337, and ENSBTAG00000051777, and also seven TFs including SOX10, GTF3C1, ETV4, MYCL, MESP1, UBTF, and MAFB were identified as key regulators in mastitis caused by Str. uberis (Supplementary file S16). Here, MESP1 is linked to mastitis.