Cystic fibrosis care has evolved steadily over the last 70-plus years, most dramatically in the past decade, with advances in diagnostic and therapeutic options including nationwide newborn screening to identify CF at birth, aggressive infection prevention, targeted nutritional support, augmentation of pancreatic function, improved mucociliary clearance, and the implementation of highly effective CFTR modulators6. This evidence concerns the gene CFTR and cystic fibrosis.