It has been observed that compared to iPD, PD with LRRK2 pathogenic mutation (LRRK2-PD) tends to exhibit a milder phenotype, and PD with GBA pathogenic mutation (GBA-PD) and PD with SNCA pathogenic mutation (SNCA-PD) are more likely to develop severe cognitive impairment12–14. This evidence concerns the gene LRRK2 and Parkinson disease.