PRMT5 and neoplasm: Also, AG-270 showed a synergistic antiproliferative effect with the anti-mitotic drug taxane in vitro and in vivo.240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5.