STAT3 and acute myeloid leukemia: Small-molecule inhibitors of STAT3 selectively kill AML stem cells and preserve normal hematopoietic cells.130 In addition, Tajan et al. found that in colon cancer, Gln deprivation stimulates p53 activation and promotes the expression of the aspartate/glutamate transporter SLC1A3, thereby promoting glutamate, Gln and nucleotide synthesis, maintaining electron transport chain and tricarboxylic acid cycle activity.