CD8A and hematologic disorder: Hope et al. found that CD8+T cells hardly express asparagine synthase (ASNS) during the early stage of CD8+T cell activation and that the growth, activation, and metabolic reprogramming of CD8+T cells are disrupted in the context of Asn deprivation.99 Wu et al. also demonstrated that Asn levels are increased in activated CD8+T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling.100 Asn also has a key role in hematological malignancies.