Meanwhile, MR can also downregulate genes involved in an inflammatory response and immune cell infiltration, such as chemokine receptor (CCRs), chemokine ligand 7 (CCL7), IL-1β, IL-6, IFN-γ, and TNF-α.262 In summary, Met restriction (MR) can alleviate diabetes by interfering with glucose homeostasis, increasing insulin sensitivity and inflammatory response. Here, INS is linked to diabetes mellitus.