Inhibition of Gln metabolism reduces the frequency of CSCs population in vivo and the rate of tumor growth in mouse models.129 Amaya et al. found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs). Here, SLC1A5 is linked to acute myeloid leukemia.