MAT2A and hepatocellular carcinoma: Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 (VCIP135) binds and stabilizes MAT2A in response to folate signaling in HCC and promotes tumor formation and progression in DEN/high-fat diet (HFD)—induced HCC mouse models (Fig. 9).239 Treatment with MAT2A inhibitors AG-24152 and AG-270 significantly reduces SAM levels, inhibits PRMT5 activity, and causes DNA damage and mitotic defects in tumor cells.