On the other hand, K108 methylation cooperates with R21 methylation to maintain low levels of OXPHOS, which favors breast cancer cell survival.198 The use of the PRMTs inhibitor MS023 in TNBC induces an interferon response and exerts an antitumor effect.199 In GBM, PRMT2 participates in oncogene transcription by mediating H3R8me2a modification.200 PRMT5 expression levels are elevated and associated with poor patient prognosis. This evidence concerns the gene PRMT5 and glioblastoma.