To assess the impact of possible imprinting from previous SARS-CoV-2 variants on the vaccine immune response, we studied IgG, IgA, nAb, and IFN-γ levels in a subcohort of individuals exposed to an earlier SARS-CoV-2 variant who experienced reinfection with Omicron (reinfected) and infection-naive individuals who experienced a primary infection with Omicron (infected with Omicron). Here, IFNG is linked to infection.