CCL2 and myopia: We then used a proinflammatory biomarker array to screen for multiple inflammatory cytokines in the blood of these mice and identified higher CCL2 level in the highly myopic mice (high myopia vs control: 99.98 ± 51.29 pg/mL vs 15.47 ± 4.57 pg/mL, respectively, P = 0.0005; high myopia vs sham: 99.98 ± 51.29 pg/mL vs 17.19 ± 5.09 pg/mL, respectively, P = 0.0006) which was not reversed after recovery of high myopia (Supplementary Fig. S3c), whereas there was no difference between the control and sham groups (Fig. 2h).