CCL2 and Anxiety: Furthermore, among highly myopic patients, those with anxiety (total anxiety score ≥ 7) displayed significantly higher CCL2 levels than those with no anxiety (39.59 ± 18.36 pg/mL vs 27.62 ± 11.90 pg/mL, respectively, P = 0.0004; Fig. 1c), suggesting that highly myopic patients with higher CCL2 levels tend to have a higher risk of anxiety.