BIRC6 and cancer: We used GEPIA2 (Gene Expression Profiling Interactive Analysis, version 2, http://gepia2.cancer-pku.cn) [37] to analyze mRNA expression level of BIRC6 (human Bruce homolog) in various human cancers, and found that BIRC6 mRNA levels are strongly increased in several cancer type, with highest expression in acute myeloid leukemia (LAML) patients (Fig. 6A).