WNT3A and hepatocellular carcinoma: To test this hypothesis, we selected two types of HCC cells for the mechanistic studies: (a) SNU475 cells that have a relatively lower level of endogenous Wnt/β‐catenin activity and can be stimulated with Wnt3a, (b) HepG2 cells that have a high level of endogenous Wnt/β‐catenin activity and cannot be stimulated with Wnt3a (Fig. 1A and Fig. S1A).