To identify global and specific trends across different HCC cell lines concerning the regulation of lipid classes and categories at the plasma membrane, we pooled all DRLs obtained in comparisons of Wnt3a/Dkk1‐treated HCC cells to untreated HCC cells as well as of untreated or Wnt3a/Dkk1‐treated HCC cells to healthy control cells. Here, DKK1 is linked to hepatocellular carcinoma.