To assess the effect of Wnt pathway manipulation by Wnt3a and Dkk1 treatment on DRLs detected in the membrane of HCC cells, we plotted a heatmap of lipid species and differential regulation contrasts in the HCC cells treated with Wnt3a or Dkk1 (Fig. S4C,D, Table S1). Here, WNT3A is linked to hepatocellular carcinoma.