LEP and Insulin resistance: Hypothalamic overexpression of a constitutively active IKKβ isoform (which is activated by saturated fatty acids and oxidative stress) can reduce both insulin and leptin signaling151; conversely, intracerebroventricular administration of an IKKβ inhibitor reverses high fat diet‐induced hypothalamic insulin resistance,157 and neuron‐specific deletion of IKKβ maintains leptin and insulin sensitivity in high fat diet fed mice.151