In rats with diet‐induced obesity from high fat diet, RYGB surgery decreased 3H‐MDL100907 binding by autoradiography (targeting 5‐HT2AR) in the nucleus accumbens (but not cortex, caudate/putamen, hippocampus, or hypothalamus) compared with sham operated rats, but no changes were seen in SERT (using (S)‐[N‐methyl‐3H]citalopram) or 5‐HT4R (using 3H‐SB207145) binding restriction.99 This evidence concerns the gene SLC6A4 and obesity due to melanocortin 4 receptor deficiency.