Based on the available reports, we found that the mRNA and protein levels of RRM2 [28], UBE2C [29], and CDK1 [30] were significantly upregulated in the large cell lung cancer cell line NCI-H460, whereas the expression of MAD2L1, KIF20A, and CCNB2 in the large cell lung cancer cell line NCI-H460 has not been reported. This evidence concerns the gene RRM2 and lung large cell carcinoma.