KEAP1 and Myocardial fibrosis: Various studies have shown that microRNA-26b inhibits isoproterenol-induced myocardial fibrosis and that this effect is mediated by the Keap1/Nrf2 signalling pathway [31], Keap1/Nrf2 plays a role in ameliorating DOX-induced myocardial fibrosis caused by H2S [32], and oxymatrine alleviates aldosterone-induced transdifferentiation of CFs into MFs in vitro by activating the Keap1/Nrf2 pathway [33].