Signaling networks such as VCAM, WNT, FN1, etc., known to be associated with dormancy escape were enriched in the DTX-treated tumor tissue, while BMP and FGF signaling networks, which are known to play a role in cancer dormancy [36,37], were enriched in VEH-treated dormant/control tumor tissue (Fig 6F). The gene discussed is FN1; the disease is cancer.