SPP1 and cancer: We identified the top 20 enriched genes in DTX- and VEH-treated mammary tumor tissue, respectively and found that Col3a1, Spp1, Vim, S100a6, Mt2, etc., which are genes associated with cancer cell proliferation, invasion, ECM remodeling, and tumor progression were enriched upon DTX treatment confirming a deleterious role of DTX in vivo (Fig 6G) [38–41].