Similarly, we have previously confirmed typical gating changes of MCC LTCC currents — i.e., activation and inactivation at more negative potentials and slower inactivation kinetics, caused by the Timothy syndrome G406R Cav1.2 variant in TS2-neo mice (corresponds to the pathogenic G407R variant in human Cav1.3) (53). This evidence concerns the gene CACNA1C and Timothy syndrome.