We have introduced the p.A749G CACNA1D mutation (human nomenclature, corresponding to mutation A771G in mice) into C57BL/6N mice using CRISPR/Cas9 (Cav1.3AG mouse line; Supplemental Figure 1, A–D; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.162100DS1), which was found in a female patient diagnosed with ASD and intellectual disability (24) and caused typical changes of Cav1.3 channel gating associated with the spectrum of clinical abnormalities associated with the human disease (20, 25–27) (Supplemental Figure 1, E and F). This evidence concerns the gene CACNA1D and Intellectual disability.