NLR family pyrin domain–containing 3 (NLRP3) inflammasome activation is tightly coordinated by collaborative action of pattern recognition receptors (PRRs), and its excessive activation is associated with various diseases including cryopyrin-associated periodic syndromes, gout, atherosclerosis, diabetes, and Alzheimer’s disease (1–5). The gene discussed is NLRP3; the disease is Alzheimer disease.