NEU1 and sialidosis: To assess the contribution of NEU1-deficient phagocytic cells to systemic pathology in sialidosis, we have generated a phagocyte-specific conditional Neu1-KO (Neu1Cx3cr1ΔEx3) and compared it with a previously described constitutive Neu1-KO mouse (Neu1ΔEx3) (30).