IRGM and infection: By contrast, during infection with Toxoplasma gondii, a pathogen for which IFN-I is host protective (4), Irgm1–/– mice had reduced survival, and this was not rescued in Irgm1–/–Ifnar–/– animals (Supplemental Figure 1A; supplemental material, including the Supplemental Methods, available online with this article; https://doi.org/10.1172/JCI171982DS1).