Gene set enrichment analysis (GSEA) was performed to assess enrichment with 27 validated RAR target genes (26 upregulated and 1 variably regulated by RA in different cell types) (50) and 3 RA regulatory genes, ALDH1A2, ALDH1A3, and CYP26B1, which are upregulated in mouse kidneys after IRI-AKI (Supplemental Table 1) (41). The gene discussed is CYP26B1; the disease is acute kidney injury.