CD206/mannose receptor+F4/80hi cells, a marker of M2 activated macrophages (72), were also reduced in PTEC DN RAR kidneys after AKI, and there was a paradoxical increase in CD206+F4/80hi KRMs in uninjured PTEC DN RAR kidneys compared with Cre– controls (Figure 10, G and H). Here, MRC1 is linked to acute kidney injury.