MLKL and acute kidney injury: Consistent with this, there was a reduction in TUNEL+ PTECs (Figure 8, A and B) and a reduction in the expression of mixed-lineage kinase domain–like protein (MLKL; a key necroptosis effector protein) (63) in PTEC DN RAR kidneys compared with Cre– controls after Rhabdo-AKI (Figure 8, C and D).