In this model, there is upregulation of PTEC and distal tubular injury markers, Kim1 and N-Gal/Lcn2 mRNAs, respectively, and upregulation of the early injury response gene, Heme Oxygenase 1 (Ho1) at 24–72 hours after AKI (Figure 2, A and B). The gene discussed is HMOX1; the disease is acute kidney injury.