The APP/PS1 mouse presents learning and memory dysfunction at 6–8 months, Aβ depositions and neuroinflammation at 6 months, increased anxiety at 12 months of age (Olensen et al. 2016) and senile plaques at 8 months (Yan et al. 2009), resembling the symptoms of early-onset familiar AD. Here, APP is linked to Alzheimer disease.