Through WGCNA, LASSO and multivariate Cox regression analyses, we identified RAB42, SH2D4A and GDF15 as high-risk hub genes for glioma, and we employed these genes to create a risk model that showed high sensitivity and specificity in prognosticating patients’ 1-, 3-, and 5-year survival (Figure 5). This evidence concerns the gene SH2D4A and glioma.