The IL18RAP mRNA levels, on the other hand, were downregulated in several cancer types, including thyroid carcinoma (THCA), rectum adenocarcinoma (READ), pancreatic adenocarcinoma (PAAD), lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), liver hepatocellular carcinoma (LIHC), colon adenocarcinoma (COAD), and bladder urothelial cancer (BLCA) (Figure 1A). This evidence concerns the gene IL18RAP and cancer.