Keeping in view the established role of CXCL2 and CXCL5 in cancer progression and metastasis, our observations pose the question of whether the increased level of serum CXCL2 and CXCL5 in AA subjects (healthy controls and prostate cancer cases) is a consequence of genetic differences or results from environmental factors, including diet and lifestyle contribute to racial disparity in prostate cancer outcomes. The gene discussed is CXCL2; the disease is prostate cancer.