FAK phosphorylation can be induced through the intracellular domain of integrin β subunit and then through src (sarcoma gene), phosphatidylinositol‐3‐kinase (PI3K) and other pathways to introduce extracellular matrix signals into the cell, activating downstream gene expression, actin polymerization, cell migration and a series of biological activities. The gene discussed is ENSG00000279284; the disease is sarcoma.