Tumour of nude mice was collected for RT‐qPCR, Western blot and IHC, which showed that expression of EZH2, p‐PI3K, p‐AKT and Ki‐67 was increased, but PTEN expression was reduced, while miR‐30b‐5p expression exhibited no difference in tumour tissues in the presence of oe‐EZH2. The gene discussed is PTEN; the disease is neoplasm.