In conclusion, it can be concluded that BMSC‐derived exosomes‐encapsulated miR‐30b‐5p could specifically inhibit EZH2 expression and PI3K/AKT signalling pathway activation to induce NSCLC cell apoptosis, thereby ultimately preventing NSCLC progression (Figure 6). The gene discussed is AKT1; the disease is non-small cell lung carcinoma.