Bruceine H, a derivative of Brucea javanica (L.), was found to overcome resistance to receptor tyrosine kinase (RTK)‐EGFRi in non‐small cell lung cancer (NSCLC) models by suppressing Notch3, EGFR activation and β‐catenin expression., thereby increasing gefitinib response. This evidence concerns the gene EGFR and non-small cell lung carcinoma.