A549 cells, expressing TRAIL‐resistant human adenocarcinoma genes, were treated with genistein (0, 10, 20 and 40 μM) which led to enhancing p62, activating Cas‐3 and Cas‐8 and increasing TRAIL‐induced tumour cell death by activated autophagy.162. The gene discussed is EFS; the disease is adenocarcinoma.