Therefore, A. vera and A. emodin could be effective in lung cancer therapy by inhibiting cell proliferation, cytoskeleton activation, stimulated cell apoptosis as well as Cas‐3 and PKC activation, MAPK signalling, inhibition of ROS production, Akt/mTOR and PI3K/AKT pathways.206. This evidence concerns the gene AKT1 and lung carcinoma.