C. longa, A. millefolium, C. sativus, szowitsiana and CURwere also found to Block the Wnt/β‐catenin and Sonic Hedgehog pathways, reduce metastasis and migration of lung cancer cells via inhibition of NF‐κB and AP‐1, MMp2, JAK/STAT3 pathways, increase FOXA2 expression via regulation of STAT3 signalling pathways, enhance GCL expression via activation of Nrf2, LC3‐II, p62 expression rand decrease cancer cell cytotoxicity via inhibition of ROS and inflammatory markers.101, 113, 130. This evidence concerns the gene NFKB1 and lung carcinoma.