Moreover, IL‐1β level in CSF was significantly and negatively correlated with the scores of VFT (r = −0.18, p = 0.043) and RFT‐imitation scales (r = −0.21, p = 0.025), while it was significantly and positively correlated with the time spent on SCWT‐A (r = 0.22, p = 0.017), SCWT‐B (r = 0.23, p = 0.013), and SCWT‐C (r = −0.29, p < 0.01) in AD patients, indicating that the elevated IL‐1β level was markedly correlated with impaired language, visuospatial ability, attention, and executive function. Here, IL1B is linked to Alzheimer disease.