YAP1 and colorectal carcinoma: Additionally, lysine demethylase 3A (KDM3A), a mono- and dimethylation of histone H3 lysine 9 (H3K9me1/2) demethylase, facilitates Yes-associated protein 1 (YAP1) expression, thus enhancing H3K27 acetylation modification in hippo target gene enhancers; furthermore, KDM3A promotes hippo target gene expression, which may facilitate the development of CRC [70].