Furthermore, the tumor suppressor abhydrolase domain containing 5 (ABHD5) interacts with DPY30, the core subunit of the SET domain containing 1A (SET1A) methyltransferase complex, promoting its ubiquitination and degradation in the cytoplasm, thereby inhibiting SET1A and upregulating c-Met expression, which promotes stemness in CRC cancer cells [73]. The gene discussed is SETD1A; the disease is cancer.