CDKN2B and colorectal carcinoma: Furthermore, protein arginine methyltransferase 5 (PRMT5), a type II arginine methyltransferase, has been identified as a promoter of CRC cell proliferation through its interaction with enhancer of zeste homolog 2 (EZH2) to inhibit cyclin-dependent kinase 4 inhibitor B (CDKN2B) expression [76].