Similarly, AT-rich interaction domain-containing protein 3B (ARID3B) is crucial for the growth of CRC and promotes the stem-like features of CRC by activating Notch target genes, intestinal stem cell (ISC) genes, and programmed death-ligand 1 (PD-L1) through the recruitment of lysine-specific demethylase 4C (KDM4C) to modulate the chromatin configuration for transcriptional activation [72]. The gene discussed is ARID3B; the disease is colorectal carcinoma.