TYMS and colorectal carcinoma: Another recent study revealed that N-alpha-acetyltransferase 40 (NAA40) affects global histone methylation and CRC cell survival through its acetyltransferase activity in stimulating transcription of the one-carbon metabolic gene thymidylate synthase (TYMS), whose product is targeted by 5-fluorouracil (5-FU) [71].