Currently, DM is considered a risk factor for COVID-19 complications and death [14, 15], probably because it leads to oxidative stress and severe glycation with overproduction of advanced glycation end products, and hyperglycemia is reported to increase the secretion of tumor necrosis factor alpha and interleukin 10, which could exacerbate inflammation [14–16]. This evidence concerns the gene TNF and Hyperglycemia.