Furthermore, eczema (p = 0.07), hearing impairment (p = 0.07), cryptorchidism (p = 0.13), and pulmonary valve stenosis (p = 0.19) were commonly found in patients with MAP2K1/2 variants, while macrocephaly (p = 0.13) was often observed in patients with BRAF variants. Here, MAP2K1 is linked to hearing loss disorder.