The exact molecular mechanism behind the protective effect of hesperetin in fibrosis is not well-defined, but the activation of AMPK/SIRT3, suppression of Glioma associated oncogene-1 (Gli-1), increased expression of Nrf2, and attenuation of the aberrant expression of patched1 in the Hedgehog pathway have been proposed as underlying mechanisms in the amelioration of liver fibrosis [37, 38, 40, 41]. The gene discussed is SIRT3; the disease is Hepatic fibrosis.