In the epigenetic mechanism, our chip-Seq and chip-qPCR disclosed H3k18la stimulates the NFκB pathway to promote SASP components IL-6 and IL-8 in senescent microglia, which suggests that the metabolic transition to aerobic glycolysis of senescent microglia aggravates brain aging and AD pathology by targeting to neuroinflammation through the H3k18la/NFκB signal axis. This evidence concerns the gene NFKB1 and Alzheimer disease.