[91] showed that the level of miR-146a was increased in the hippocampus of APP/PS1 AD model mice injected with bone marrow mesenchymal stem cells (BM-MSCs), and this upregulation was caused by the secretion of exosomal miR-146a from BM-MSCs and involved in the correction of cognitive impairment. This evidence concerns the gene APP and Alzheimer disease.