Through a method of isolating neuron-derived EVs from plasma based on neuronal expression of L1 cell adhesion molecule (L1CAM), one study showed that the levels of miR-23a-3p, miR-223-3p, and miR-190a-5p in neuron-derived EVs isolated from the plasma of AD patients were significantly increased, whereas the level of miR-100-3p was significantly decreased [89]. Here, L1CAM is linked to Alzheimer disease.