Several genes mapped to DMRs of at-birth blood samples of the winter-born of the higher latitude, not found in the lower latitude, had links to immunity and inflammation (LAX1: T-/B-/NK-cell activation; TLR5: pathogen recognition; LTB4R: pathogenesis of inflammatory diseases; PSORS1C3: psoriasis; TCL1A: modulation of immune responses; ADAM5: autoimmune diseases) [54, 62–64, 73–76]. Here, TLR5 is linked to autoimmune disease.