Stolzenberg-Solomon et al. conducted a study on 29,133 Finnish male, and they found that higher fasting glucose, insulin levels, and insulin resistance were positively linked to PDAC, Given that obesity is associated with insulin resistance in almost all subjects, hyperinsulinemia is believed to play a causative role in the development of PDAC [8]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.