We found that inflammation-related genes IL15, IL2, IL21, IL20, IL20, IL22RA2, IL20RB, and IL10 associated with IFN-λ expression promote inflammatory response signaling, suggesting that patients with endogenous IFN-λ expression may enhance the inflammatory environment and response in tumor lesions due to the upregulated expression of these genes. This evidence concerns the gene IL21 and neoplasm.