Hyperglycemia and nuclear factor-kappaB (NF-κB) hypertension are the main risk factors for DMO, which primarily destroys the blood-retinal barrier by altering endothelial growth factor (VEGF) and pro-inflammatory cytokines pro- inflammatory cytokines, which can lead to vascular leakage and ultimately to blindness [2]. This evidence concerns the gene NFKB1 and Hyperglycemia.