Researchers studied inducible human NOX5 transgenic mice in an oxygen-induced retinopathy model by in vitro and in vivo experiments and found that NOX5 significantly induced oxidative stress and elevated VEGF and intercellular adhesion factor levels, which in turn exacerbated neovascularization and vascular infiltration and increased damage to the visual system, and it was also demonstrated that inhibition of NOX1/4 expression and NOX5-siRNA reduced high glucose-induced oxidative stress, angiogenesis, and upregulation of inflammatory factors [8]. Here, NOX5 is linked to retinal disorder.