It was believed that PVT1 combined with miR-146a induced the change of pulmonary function in COPD smokers [50], PVT1 should have the ability to predict COPD susceptibility and acute exacerbation risk and be correlated with GOLD stage and inflammatory cytokine levels in AECOPD patients and stable COPD patients [29, 35]. The gene discussed is PVT1; the disease is chronic obstructive pulmonary disease.