IL1B and chronic obstructive pulmonary disease: For example, upregulated expression of the lncRNA NEAT1 is positively correlated with the The Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and the levels of inflammatory cytokines tumor necrosis factor (TNF)-a, interleukin (IL)-1β, IL-6, and IL-17 in acute exacerbations of COPD (AECOPD) patients and stable COPD patients, suggesting that NEAT1 is susceptible to COPD, related to the risk of acute attacks, and is positively related to the severity of the disease and inflammation [13, 15].