Elegant work has shown that very limited alveolar epithelial ACE2 protein expression limits alveolar permissiveness for SARS-CoV-2, and Hönzke, Obermayer [19] concluded that COVID-19 ARDS is “likely caused by secondary immunopathogenesis rather than direct alveolar viral damage”, with SARS-CoV-2 virions, ingested by Alveolar Macrophages strongly implicated [19]. Here, ACE2 is linked to COVID-19.