By analyzing gene data of 325 tumor tissue samples and 20 normal tissue samples obtained from the CGGA RNA-seq set and 153 tumor tissue samples and 23 normal tissue samples in GSE 4290 array set, we observed lower expression of CACNG3 in gliomas compared to matched normal tissues, specifically in high-grade gliomas (HGG, WHO Grade IV) (Fig. 1A-D). The gene discussed is CACNG3; the disease is central nervous system cancer.