EGF and neoplasm: Among the 19 down-regulated DEGs, members of typeI and typeIII collagen (COLA) account for a high proportion, which had been reported in previous studies that its expression could be enhanced by the epidermal growth factor (EGF) [18], a protein that activates epidermal growth factor receptor (EGFR) on tumor cells, leading to accelerated tumor growth and poor prognosis [19].