Univariate regression analysis results revealed that CACNG3, together with other clinical characteristics including Age (P < 0.0001), IDH mutation status (P < 0.0001), 1p/19q codeletion status (P < 0.0001), and Grade (P < 0.0001) were closely related to patients’ overall survival and could be used to predict OS of gliomas of all grades. Here, CACNG3 is linked to central nervous system cancer.