Therefore, one of the reasons why anti-rabphilin-3A antibodies are detected in patients with LINH, but not in patients with germinoma and other tumors, could be that abnormalities in immunocompetent cells, such as lymphocytes that infiltrate the neurohypophysis and react to rabphilin-3A, may be involved in the pathogenesis of LINH. This evidence concerns the gene RPH3A and germinoma.