Watanabe et al. reported that concentrations of CSF PLAP in germinoma cases were significantly elevated (median CSF PLAP level 425 pg/mL, range 16 to 3700 pg/mL, n = 36) and the sensitivity and specificity of a PLAP assay for germinomas were 94 and 97%, respectively, with a cut-off value of 30 pg/mL [21]. This evidence concerns the gene ALPP and germinoma.