INS and diabetes mellitus: The samples within MIA vary in sex, age (ranging from embryonic to postnatal, to adult, to aged), application of chemical stressors implicated in the loss of cellular identity (FoxO inhibitor and artemether) and disease status (diabetes models, NOD, db/db and multiple low-dose STZ (mSTZ) together with different anti-diabetic treatments (vertical sleeve gastrectomy (VSG), insulin, glucagon-like peptide 1 (GLP-1) and estrogen) (Fig. 2a).