INS and diabetes mellitus: We next profiled three new markers of the T2D model: Nucb2, which is involved in insulin secretion115,116 and whose mutations were reported to be associated with diabetes risk117, Fkbp11, an ER-located chaperone previously reported to be upregulated in certain mouse T2D models118,119 and Mt3, which was reported to be associated with β-cell death120.