The intermediate state contained both stressed healthy and diabetic cells (Extended Data Fig. 5d and Supplementary Note 7), including cells from the Feng dataset mapped onto MIA (Fig. 4c); however, the sample with the largest cell proportion localizing in this state was the mSTZ diabetes model sample with regenerative anti-diabetic treatment30 (GLP-1 + estrogen + insulin; Extended Data Fig. 5d). Here, INS is linked to diabetes mellitus.