EFEMP1 and infarction: Our RNA-seq analysis clearly demonstrated that although fibulin-3 expression in fibroblasts was reduced in the interstitial cell population early following infarction (day-1 to -7), fibulin-3 was in fact upregulated to its highest levels at much later time-points, from between 28 days to 8 weeks post-MI when fibrosis is well established.