EFEMP1 and myocardial infarction: Finally, we demonstrated that fibulin-3 deletion alters scar tissue integrity, specifically resulting in less collagen deposition and increased Mmp9 expression early at day-3 post-MI, significantly increasing rates of death due to cardiac rupture in the border zone at days 3–6, and increasing ventricular remodelling, with no difference in collagen deposition, at day-28.