Finally, to unbiasedly interrogate the effect of fibulin-3 deletion further and identify potential mechanisms of cardiac rupture in Efemp1−/− mice post-MI, we conducted bulk RNA-seq on infarct zone tissue of Efemp1−/− and WT mice at this early day-3 post-MI time-point. Here, EFEMP1 is linked to myocardial infarction.