The top 10 signalling pathways selected by activation prediction score (positive z-score) were: Integrin-linked kinase (ILK), BRCA1, Dilated Cardiomyopathy Signaling Pathway, Protein Kinase A, Actin Cytoskeleton, AMPK signaling, Epithelial Adherens Junction, Oxytocin Signaling Pathway, Integrin Signaling and CNTF Signaling (Fig. S3). This evidence concerns the gene BRCA1 and cardiomyopathy.