The top 10 up-regulated pathways were: epidermal growth factor (EGF), integrin, platelet derived growth factor (PDGF), PYK2, melanoma, p38, mitogen activated protein kinases (MAPK) family signaling cascades, target of rapamycin (mTOR) signaling, regulation of Ras by GTPase activating proteins (GAPs), signaling by fibroblast growth factor receptor 2 (FGFR2) (Table S3). This evidence concerns the gene PTK2B and melanoma.