APC and adenoma: Multiple intestinal neoplasia (Min) mice, containing a point mutation in the Adenomatous polyposis coli (APC) gene in a C57BL/6 background (C57BL/6 APCMin/+  = APCMin/+)38, develop numerous adenomas in the small intestine and was the first model used to demonstrate the involvement of the APC gene in intestinal tumorigenesis39,40.