TREM2 and neoplasm: Within the identified myeloid sub-types a higher relative expression of triggering receptor expressed on myeloid cells 2 (TREM2), a known marker for recurrence, was identified within a larger proportion of pro-tumour TAM sub-types in HG_3 TME; whilst an absence of immunosuppression markers human leucocyte antigen G (HLA-G) and cysteine protease cathepsin S (CTSS)18,19 was observed within TAM ISG high expression (TAM ISGhi) in HG_3 and HG_2 TME, respectively (Supplementary Fig. 1).