BCL2 and asthma: For example, one study reported that the levels of circulating ILC2s from steroid-resistant asthma patients increase after steroid treatment; moreover, circulating ILC2s from healthy humans are related to steroid resistance mediated by high expression of the anti-apoptotic genes BCL2 and BCL2L1. The ratio of the proapoptotic genes BAX1 and BAK1 to the anti-apoptotic gene BCL2 was significantly decreased in ILC2s46.