However, given the plethora of evidence reporting that astroglia reductions in the PFC of MDD post-mortem and rodent chronic stress models seem to affect preferentially the GFAP+ cell population [8, 28, 29, 47, 48], we felt necessary to explore the specific contribution of GFAP+ cell pathology in the development of depressive-like behavior. The gene discussed is GFAP; the disease is major depressive disorder.